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Pulished Date February, 2020
ID: 4431
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Global Blood Brain Barrier Technologies Market Analysis - Industry Size, Share, Growth, Trends, Forecast | 2019 – 2024

Pulished: February, 2020
ID: 4431
Pages: 175

Industry Analysis

As per our report, the Global Blood-Brain Barrier Technologies Market is to grow at a remarkable CAGR of 22% from 2019 to 2024. Advances in biotechnology have enabled the development of versatile in-vitro, in-vivo, in-situ blood-brain barrier models, allowing more effective and safe delivery of drugs across brain capillaries.

The blood-brain barrier plays a vital role in protecting the brain from blood-borne diseases and toxic compound as they help the people suffering from neural diseases like brain cancer Alzheimer. Alzheimer requires the development of new drugs such as recombinant protein or gene therapies; there is an excellent scope for the development of new drugs for the brain as there was no new approval for new recombinant drug by the FDA. Thus low weight molecule drugs and biomacromolecules such as DNA and protein are used for the treatment of neurological diseases. There are many types of research going on to develop new techniques for entry of the drug in the brain without damaging the blood-brain barrier membrane.

Epilepsy, sclerosis, obesity, Alzheimer, Parkinson, neurotransmitter are neurologic are few of the areas to which several patents on the BBB technologies being exploited for designing drugs against widespread CND disorders. Over the years, more than 16700 patents related to BBB technologies have been granted to various industry and non-industry players, indicating the pace of R&D activity in this burgeoning field of research. Around 62% of patents related to BBB technologies have been granted in the United States; the Asia Pacific followed this with more than 2300 patents.

COVID-19 impact on Global BBB Technologies Market

  • Lack of oxygen reaching the brain cells for a long time can be damaging to the brain in COVID-19 patients, which can lead to death.
  • Recent clinical studies indicate that people suffering from CNS complications are more susceptible to COVID-19 infection due to the compromised immune system.
  • Several infected have been reported to suffer from mild neurological symptoms such as acute stroke and brain tumours.

The brain is one of the most extensive and most intricate organs in the human body. It consists of 100 billion nerves that communicate with 100 trillion synapses. It is up of midbrain, hindbrain, and forebrain. It is responsible for movement and thought produced by the body. It has its own security system-a filtering mechanism consisting of blood vessels that allow entry of essential nutrients at the same time blocking other substances-known as the blood-brain barrier. The blood-brain barrier is a semi-permeable dynamic interface that separates the capillaries which carry blood to the brain and spinal cord tissue by blocking the passage of certain substances. The vessels of the blood-brain barrier are up of specialized endothelial cells which lines brain capillaries from the vascular system, which lack the fenestration of pores and allow rapid exchange of molecules between vessels and tissues. The blood-brain barrier protects the neural tissue from harmful chemicals and maintains a stable environment.

However, this barrier is so effective at blocking the entry of foreign substances that it often prevents penetration of life-saving drugs to address issues like injuries and diseases. Therefore, the discovery of new methods allowing the effective delivery of medicines and bio-macromolecules to the central nervous system (CNS) is of immense importance for the treatment of neurodegenerative disorders.

MARKET DRIVERS

Growing burden related to CNS is the significant growth driving force to the global blood-brain technologies market.

Effective drug delivery across the blood-brain barrier is one of the most impediments to the successful treatment of CNS related diseases and brain tumours. Around 1.5 billion people are affected by CND related infections globally. The global CNS Drugs market has a market worth of more than 125 billion USD. More than 100 drugs, capable of penetrating this elusive barrier are currently being evaluated for the treatment of CNS treatments; there are 25+ technology platforms for the development of BBB penetrant drugs.

The public and the private organization are increasing the funds for the research of the blood-brain barrier technology, and it is propelling the market growth. The research team from the Kumamoto University Japan is working on developing a cyclic peptide. There is research going on to create a variety of invasive and non-invasive technique to deliver drugs through the blood-brain barrier without disrupting the membrane. The monoclonal antibody can penetrate through the blood-brain barrier.

Additionally, the growing prevalence of neurological diseases like Parkinson's disease, meningitis, multiple sclerosis, and encephalitis, augmenting geriatric population and rising healthcare expenditure is further accelerating the market growth. Furthermore, increasing investment in R&D for the development of new drugs and delivery devices, growing awareness about healthcare and an increasing number of initiatives by various governments and affiliated associations are projected to fuel the blood-brain barrier technologies market.

MARKET RESTRAINTS

On the other hand, intricate regulatory frameworks for the approval of drugs in most countries and inordinate approval time for medications due to the insufficient knowledge of the brain are primary restraints for the growth of the market. People in rural areas are less aware of latest technologies where this is slowly inhibiting the demand of the market. Lack of proper knowledge in the procedure due to less training programs by the government is hindering the growth rate of the market.

REPORT COVERAGE

REPORT METRIC

DETAILS

Market Size Available

2018 to 2024

Base Year

2018

Forecast Period

2019 to 2024

Various Analyses Covered

Global, Regional & Country Level Analysis, Segment-Level Analysis, Drivers, Restraints, Opportunities, Challenges, PESTLE Analysis, Porter's Five Forces Analysis, Competitive Landscape, Analyst Overview on Investment Opportunities

Regions Covered

North America, Europe, Asia Pacific, Latin America, Middle East & Africa

 

Regional Insights

North America leads the global market, given the increasing incidence of neurological diseases and augmenting the geriatric population in the region.

Asia is to show high growth rates in the forecast period in the market, with China and India being the fastest-growing markets in the Asia Pacific. The primary driving forces for the market in emerging economies are the large pool of patients, growing awareness about the disease, improving healthcare infrastructure, and increasing government funding in the region.

Top companies in the market

Key market participants leading the Global Blood-Brain Barrier Technologies Market are Bristol-Myers Squibb Company, Pfizer, Inc., biOasia Technologies, Inc., Cypress Biosciences, Inc., Janssen Pharmaceutical N.V., Teva Pharmaceuticals Industries, Ltd., F. Hoffmann La-Roche, Ltd., Eli Lilly and Company, Fabre-Kramer Pharmaceuticals, Inc., NeuroVive Pharmaceutical AB, and ArmaGen.

Several technology developers are presently focussing on the integration of the advanced technical features into their proprietary drug development or delivery platforms to achieve the competitive edge. An assessment of 240+ drug developers focused on Parkinson's and Alzheimer's diseases, revealed that many firms are likely to partner with technology providers to leverage their BBB penetration expertise.

RECENT MARKET DEVELOPMENTS

On May 27 2020, Denali Therapeutics Inc., a biopharmaceutical company has announced the publication of two new therapies related to the blood-brain barrier.

On May 28 2020, CNS Pharmaceutical announced that it had signed an agreement with MD Anderson for potential brain cancer treatment.

On June 1 2020, Hesperos announced that the human–on–a–chip system can be used as a drug discovery platform for the preclinical Alzheimer.

1. Introduction                                 

                1.1 Market Definition                    

                1.2 Study Deliverables                  

                1.3 Base Currency, Base Year and Forecast Periods                          

                1.4 General Study Assumptions                

2. Research Methodology                                           

                2.1 Introduction                               

                2.2 Research Phases                      

                                2.2.1 Secondary Research           

                                2.2.2 Primary Research 

                                2.2.3 Econometric Modelling      

                                2.2.4 Expert Validation  

                2.3 Analysis Design                         

                2.4 Study Timeline                          

3. Overview                                       

                3.1 Executive Summary                

                3.2 Key Inferences                         

                3.3 Epidemology                              

4. Drivers, Restraints, Opportunities, and Challenges Analysis (DROC)                                    

                4.1 Market Drivers                          

                4.2 Market Restraints                    

                4.3 Key Challenges                         

                4.4 Current Opportunities in the Market                              

5. Market Segmentation                                              

                5.1 Geography                 

                                5.1.1 Introduction           

                                5.1.2 North America       

                                5.1.3 Latin America         

                                5.1.4 Europe      

                                5.1.5 Asia Pacific              

                                5.1.6 Middle East and Africa       

                                5.1.7  Y-o-Y Growth Analysis, By Geography        

                                5.1.8  Market Attractiveness Analysis, By Geography      

                                5.1.9  Market Share Analysis, By Geography       

6. Geographical Analysis                                              

                6.1 Introduction                               

                                6.1.1 Regional Trends    

                                6.1.2 Impact Analysis     

                                6.1.3 Y-o-Y Growth Analysis        

                                                6.1.3.1 By Geographical Area

                                6.1.4  Market Attractiveness Analysis     

                                                6.1.4.1 By Geographical Area

                                6.1.5  Market Share Analysis      

                                                6.1.5.1 By Geographical Area

                6.2 North America                          

                                6.1.1 Introduction           

                                6.1.2 United States         

                                6.1.3 Canada     

                6.3 Europe                         

                                6.2.1 Introduction           

                                6.2.2 U.K             

                                6.2.3 Spain         

                                6.2.4 Germany 

                                6.2.5 Italy            

                                6.2.6 France       

                6.4 Asia-Pacific                 

                                6.3.1 Introduction           

                                6.3.2 China         

                                6.3.3 India          

                                6.3.4 Japan         

                                6.3.5 Australia   

                                6.3.6 South Korea           

                6.5 Latin America                             

                                6.4.1 Introduction           

                                6.4.2 Brazil          

                                6.4.3 Argentina

                                6.4.4 Mexico     

                                6.4.5 Rest of Latin America          

                6.6 Middle East & Africa                               

                                6.5.1 Introduction           

                                6.5.2 Middle-East            

                                6.5.3 Africa         

7. Strategic Analysis                                       

                7.1 PESTLE analysis                         

                                7.1.1 Political     

                                7.1.2 Economic 

                                7.1.3 Social         

                                7.1.4 Technological         

                                7.1.5 Legal          

                                7.1.6 Environmental       

                7.2 Porter’s Five analysis                              

                                7.2.1 Bargaining Power of Suppliers        

                                7.2.2 Bargaining Power of Consumers    

                                7.2.3 Threat of New Entrants     

                                7.2.4 Threat of Substitute Products and Services              

                                7.2.5 Competitive Rivalry within the Industry     

8. Market Leaders' Analysis                                        

                8.1 Allon Therapeutics, Inc.                         

                                8.1.1 Overview 

                                8.1.2 Product Analysis   

                                8.1.3 Financial analysis  

                                8.1.4 Recent Developments       

                                8.1.5 SWOT analysis       

                                8.1.6 Analyst View          

                8.2 AngioChem Inc.                        

                8.3 Genzyme                    

                8.4 CeNeRx BioPharma, Inc                        

                8.5 Bioasis Technologies Inc.                      

                8.6 Ablynx NV                   

                8.7 Capsulution Pharma AG                        

                8.8 International Brain Barriers Society (IBBS)                     

                8.9 Cephalon Inc                              

                8.10 Cognition Pharmaceuticals LLC                         

9. Competitive Landscape                                           

                9.1 Market share analysis                            

                9.2 Merger and Acquisition Analysis                       

                9.3 Agreements, collaborations and Joint Ventures                         

                9.4 New Product Launches                         

10. Market Outlook and Investment Opportunities                                         

Appendix                                           

                a) List of Tables                

                b) List of Figures                              

  • Global, regional and country-level analysis and forecasts of the study market; providing Insights on the major countries/regions in which this industry is blooming and to also identify the regions that are still untapped
  • Segment-level analysis in terms by type, packaging and meat type along with market size forecasts and estimations to detect key areas of industry growth in detail
  • Identification of key drivers, restraints, opportunities and challenges (DROC) in the market and their impact on shifting market dynamics
  • Study of the effect of exogenous and endogenous factors that affect the global market; which includes broadly demographic, economic and political, among other macro-environmental factors presented in an extensive PESTLE Analysis
  • Study the micro environment factors that determine the overall profitability of an Industry, using Porter’s five forces analysis for analyzing the level of competition and business strategy development
  • A comprehensive list of key market players along with their product portfolio, current strategic interests, key financial information, legal issues, SWOT analysis and analyst overview to study and sustain the market environment
  • Competitive landscape analysis listing out the mergers, acquisitions, collaborations in the field along with new product launches, comparative financial studies and recent developments in the market by the major companies
  • An executive summary, abridging the entire report in such a way that decision-making personnel can rapidly become acquainted with background information, concise analysis and main conclusions
  • Expertly devised analyst overview along with Investment opportunities to provide both individuals and organizations a strong financial foothold in the market
  1. Global Blood Brain Barrier Technologies Market By Region, From 2019-2024 ( USD Million )
  2. Global Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  3. Global Market By Region, From 2019-2024 ( USD Million )
  4. Global Market By Region, From 2019-2024 ( USD Million )
  5. Global Market By Region, From 2019-2024 ( USD Million )
  6. Global Market By Region, From 2019-2024 ( USD Million )
  7. Global Market By Region, From 2019-2024 ( USD Million )
  8. North America Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  9. North America Market By Region, From 2019-2024 ( USD Million )
  10. North America Market By Region, From 2019-2024 ( USD Million )
  11. North America Market By Region, From 2019-2024 ( USD Million )
  12. North America Market By Region, From 2019-2024 ( USD Million )
  13. North America Market By Region, From 2019-2024 ( USD Million )
  14. United States Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  15. Canada Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  16. Europe Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  17. Europe Market By Region, From 2019-2024 ( USD Million )
  18. Europe Market By Region, From 2019-2024 ( USD Million )
  19. Europe Market By Region, From 2019-2024 ( USD Million )
  20. Europe Market By Region, From 2019-2024 ( USD Million )
  21. Europe Market By Region, From 2019-2024 ( USD Million )
  22. U.K. Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  23. Germany Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  24. France Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  25. Italy Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  26. Spain Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  27. Asia Pacific Blood Brain Barrier Technologies Market By Geography, From 2019-2024 ( USD Million )
  28. Asia Pacific Market By Region, From 2019-2024 ( USD Million )
  29. Asia Pacific Market By Region, From 2019-2024 ( USD Million )
  30. Asia Pacific Market By Region, From 2019-2024 ( USD Million )
  31. Asia Pacific Market By Region, From 2019-2024 ( USD Million )
  32. Asia Pacific Market By Region, From 2019-2024 ( USD Million )
  33. Japan Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  34. China Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  35. India Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  36. Australia Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  37. South Korea Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  38. Latin America Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  39. Latin America Market By Region, From 2019-2024 ( USD Million )
  40. Latin America  Market By Region, From 2019-2024 ( USD Million )
  41. Latin America  Market By Region, From 2019-2024 ( USD Million )
  42. Latin America  Market By Region, From 2019-2024 ( USD Million )
  43. Latin America  Market By Region, From 2019-2024 ( USD Million )
  44. Brazil Blood Brain Barrier Technologies Market  By Geography, From 2019-2024 ( USD Million )
  45. Argentina Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  46. Mexico Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  47. Rest of Latin America Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  48. Middle East and Africa Blood Brain Barrier Technologies  Market By Geography, From 2019-2024 ( USD Million )
  49. Middle East and Africa  Market By Region, From 2019-2024 ( USD Million )
  50. Middle East and Africa  Market By Region, From 2019-2024 ( USD Million )
  51. Middle East and Africa  Market By Region, From 2019-2024 ( USD Million )
  52. Middle East and Africa  Market By Region, From 2019-2024 ( USD Million )
  53. Middle East and Africa Market By Region, From 2019-2024 ( USD Million )
  54. Middle East Blood Brain Barrier Technologies Market  By Geography, From 2019-2024 ( USD Million )
  55. Africa Blood Brain Barrier Technologies Market  By Geography, From 2019-2024 ( USD Million )

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