Global Membrane Chromatography Market Size, Share, Trends, COVID-19 Impact & Growth Analysis Report – Segmented By Product, Application, End-user & Region - Industry Forecast (2024 to 2029)

Updated On: January, 2024
ID: 12572
Pages: 190

Membrane Chromatography Market Size (2023 to 2028)

As per our analysis report, the global membrane chromatography market size is forecasted to be worth USD 426.3 million by 2028 from 190.35 million in 2023. The market is expected to accelerate at a CAGR of 17.5% from 2023 to 2028.

Chromatography is an essential biophysical technique that provides the separation, identification, and purification of the components of a mixture for qualitative and quantitative analysis. Membrane chromatography is a well-established technology in bioprocessing. The absence of pore diffusion, the primary transport resistance in conventional column chromatography using porous particles, is the main feature of chromatographic separations based on membranes and is mainly used to capture large particles such as viruses and viral vectors. It introduced an integrative technology for the purification of proteins several years ago. In addition, membrane chromatography provides advantages for applications that do not require high-resolution separation.

Impact of COVID-19 on the global membrane chromatography market:

Covid-19 has spread worldwide in a short period resulting in millions of deaths. The possible use of hydroxychloroquine (HCQ) and chloroquine (C.Q.) as treatments. HCQ can be essential in several steps of the coronavirus replication cycle. It is commonly agreed that the main two binding sites for severe acute respiratory syndrome are coronavirus spike glycoprotein (Spike) and receptor ACE2 (SARS-CoV). The new coronavirus enters the human body by interacting with the ACE2 protein through its Spike protein. Therefore, to avoid COVID-19 virus infection, blocking or antagonizing the ACE2 signal pathway of sensitive cells is useful. Considering all these factors, the market has mild growth and will increase its growth in the coming years.


The advantages of membrane chromatography over conventional chromatography technologies are one of the major factors promoting the membrane chromatography market.

The growing usage of ingle-use membrane chromatography is also anticipated to boost the market’s growth rate. Devices for ready-to-use membrane chromatography are available in a variety of sizes useful for manufacturing as well as process development. For example, for use in flow-through polishing, different modalities have membrane bed heights of 4 mm or 8 mm. 3 M's anion exchange (AEX) chromatography, a single-use hybrid purifier is designed for bringing chromatography into upstream processing for particle control and reduction of DNA and host cell proteins.

Membrane chromatography is used in the purification process and acts as an opportunity for market growth.

Chromatography is based on the principle that molecules in a mixture are applied onto the surface or into the solid, and the stationary fluid phase is separated from each other. The purification process requires a more robust separation technique to streamline without compromising critical quality attributes. Due to the interactions between the target molecules and the immobilized ligand, affinity chromatography is one of the most effective separation techniques. It potentially enables a platform-able purification strategy where each molecule can be purified with a different affinity media followed by one or two polishing steps.


On the other hand, less usage of membrane chromatography is the major restraint for market growth. Furthermore, a lack of skilled professionals and a lack of awareness among people is further anticipated to hinder the growth rate of the membrane chromatography market.




Market Size Available

2022 to 2028

Base Year


Forecast Period

2023 to 2028

Segments Covered

By Product, Region, Application & End-user

Various Analyses Covered

Global, Regional & Country Level Analysis, Segment-Level Analysis, Drivers, Restraints, Opportunities, Challenges, PESTLE Analysis, Porter's Five Forces Analysis, Competitive Landscape, Analyst Overview of Investment Opportunities

Regions Covered

North America, Europe, APAC, Latin America, Middle East & Africa


This research report has segmented the global membrane chromatography market into the following categories: product, application, end-user & region.

Membrane Chromatography Market – By Product:

  • Affinity Membrane Chromatography
  • Hydrophobic Interaction Membrane Chromatography (HIMC)
  • Ion Exchange Membrane Chromatography

Based on the product, the Ion-exchange membrane chromatography segment accounted for the largest share of the market in 2022. Ion-exchange chromatography is one of the separation processes for purifying proteins and complex bio-structures such as viruses, e.g., rotavirus-like particles (RLPs). The construction of highly efficient monolithic ion exchange columns is essential for the advancement of I.C., and solving issues will be necessary for the development. Based on their respective charged groups, Ion-exchange chromatography separates molecules. Ion-exchange chromatography maintains analyte molecules on the column based on columbic (ionic) interactions. Proteins are separated from the column either by changing pH, the concentration of ion salts, or the ionic strength of the buffer solution. Anion-exchange matrices are positively charged ion-exchange materials that attract negatively charged proteins.

Membrane Chromatography Market – By Application:

  • Chemical
  • Sewage Treatment

Membrane Chromatography Market – By End-User:

  • Pharmaceutical and Biopharmaceutical Companies
  • CROs
  • Academic and Research Institutes

Based on the end-user, the pharmaceutical and biopharmaceutical companies segment led the market in 2022. Humulin was introduced in 1982. It was the first biopharmaceutical product to receive Food and Drug Administration approval in the U.S. Food and Drug Administration. Humulin from a protein mixture was initially used in high-performance liquid chromatography (HPLC). Since then, hundreds of biopharmaceuticals that have reached the market in the past 40 years have been purified using chromatography.

Membrane Chromatography Market – By Region:

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Middle East and Africa

Geographically, North America dominated the membrane chromatography market worldwide in 2022, owing to the presence of the biopharmaceutical industries. In addition, U.S. and Canada have the highest growth due to increasing pharmaceutical research and development. The Chromatography Institute of America was founded on the principle that independent bodies that facilitate the flow of information on chromatography instrumentation should better serve laboratories and instrument suppliers.

The Asia Pacific is expected to have market share due to the growing biopharmaceutical industry, increasing investments by key market players, increasing awareness among people in this region, and increasing government support. Japan has the highest portion in the Pacific region. Japan is in third place in pharmaceutical market development in the world. The Japanese biopharmaceutical market was valued at 2.1 trillion yen in 2021.

Key Market Participants:

Companies playing a notable role in the global membrane chromatography market profiled in this report are Sartorius AG, Danaher Corporation, Merck Millipore, Thermo Fisher Scientific, 3M Company, GE Healthcare, Asahi Kasei Corporation, Cole-Parmer Instrument Company, LLC, GL Sciences Inc., Regis Technologies, Inc. and Restek Corporation.


  • In 2020, Danaher Corporation, global science and technology innovator announced the completion of its acquisition of the Biopharma business from General Electric Company's Life Sciences division. It helps its customers in resolving challenging issues and improving standards of living globally.
  • In 2021, Sartorius Stedim Biotech, a leading international partner in the biopharmaceutical industry, signed an agreement with McMaster University to improve the manufacturing processes of antibody and virus-based treatments for diseases.

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Frequently Asked Questions

What was the size of the membrane chromatography market worldwide in 2021?

The global membrane chromatography market size was valued at USD 138 million in 2021.

Which region is growing the fastest in the global membrane chromatography market?

Geographically, the APAC region is expected to grow the fastest and register a CAGR of 19.63% from 2022 to 2027.

Which segment by product held the significant share in the membrane chromatography market in 2021?

Based on the product, the ion exchange segment accounted for the major share of the market in 2021. 

Which are the significant players operating in the membrane chromatography market?

Sartorius AG, Danaher Corporation, Merck Millipore, Thermo Fisher Scientific, 3M Company, GE Healthcare, Asahi Kasei Corporation, Cole-Parmer Instrument Company, LLC, GL Sciences Inc., Regis Technologies, Inc. and Restek Corporation are some of the noteworthy players in the membrane chromatography market.

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