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Global Protein Expression Market Size, Share, Trends, COVID-19 Impact & Growth Analysis Report – Segmented By Expression Systems (Yeast Expression, Insect Expression, Cell-Free Expression, Bacterial Expression, Algal Expression and Mammalian Expression), Application, End User & Region - Industry Forecast From 2023 to 2028

Published: March, 2023
ID: 734
Pages: 170
Formats: report pdf report excel report power bi report ppt

Global Protein Expression Market Size (2023 to 2028)

The global protein expression market is estimated to be worth USD 3002 million by 2028 and USD 1940 million by 2023, growing at a CAGR of 9.12% during the forecast period.

Protein expression can closely relate to gene expression as the proteins' blueprints are commonly stored in the DNA. This process involves transcribing DNA molecules to produce RNA and translating RNA to form a protein. When double-stranded DNA is unwounded, it allows us to bind RNA polymerase, initiating the transcription process. The translation process may get started before completing the transcription process when a mature RNA molecule is released. The protein expression process's main aim is to generate specific proteins with high quality using living organisms.


Rising support from private and public organizations through investments in the biotechnology field is undoubtedly a significant factor propelling the demand of the global protein expression market. An increasing number of research institutes in the life sciences sector is also accelerating market demand. The growing prevalence of effective treatment procedures is significantly influencing the market's growth.

Growing incidences of chronic diseases worldwide are setting up growth opportunities for the market. Furthermore, increasing the adverse effects of molecular drugs are making people shift towards biologics, lavishing the demand of the global protein expression market.


However, the cost of installing and maintaining equipment in laboratories impedes the demand of the global protein expression market. The lack of skilled persons to analyze the final outputs inconvenient way also reduces the market's fastest growth. Lack of standardization is another attribute hampering the demand of the market.




Market Size Available

2022 to 2028

Base Year


Forecast Period

2023 to 2028

Segments Covered

By Expression Systems, Products, End-User, and Region

Various Analyses Covered

Global, Regional & Country Level Analysis, Segment-Level Analysis, DROC, PESTLE Analysis, Porter’s Five Forces Analysis, Competitive Landscape, Analyst Overview on Investment Opportunities

Regions Covered

North America, Europe, APAC, Latin America, Middle East & Africa


This research report on the global protein expression market has been segmented and Sub-segmented based on the expression systems, products, end-user, and regions.

Protein Expression Market – By Expression Systems:

  • Yeast Expression
  • Insect Expression
  • Cell-Free Expression
  • Bacterial Expression
  • Algal Expression
  • Mammalian Expression

Based on the expression system, the bacterial expression system segment is predicted to hold the largest share of the global protein expression market during the forecast period. In contrast, the mammalian expression system segment is projected to grow at the highest CAGR during the forecast period due to the increasing demand for therapeutic proteins essential for humane treatment. 

The mammalian expression segment is projected to exhibit the highest growth rate during the forecast period by expression systems. The growth is due to the escalating popularity of the designs for biopharmaceuticals and research applications growing with profitable market growth over the analysis period.

The insect and cell expression are expected to perform well during the forecast period due to the growing focus on proteomics research, intensifying government support for research activities, and easy availability of advanced systems Bac-to-Bac expression system.

Protein Expression Market – By-Products:

  • Reagents
  • Services
  • Instruments
  • Others

Based on products, the reagents segment had the largest share of the worldwide market in 2022 and is expected to grow at a healthy CAGR during the forecast period owing to the increasing number of patients suffering from genetic diseases and the frequent purchase of reagents for various applications.

The services segment is to have the quickest growing rate during the forecast period due to the rising trend for characteristic optimization of protein expression. In addition, the service providers are prepared with advanced products and research specialists. These factors surge the demand for protein expression services by manufacturers and research laboratories.

Protein Expression Market – By Application:

  • Industrial Proteins
  • Cell Culture
  • Research
  • Therapeutic Proteins
  • Transfection Technologies
  • Others

Based on the application, Therapeutic protein applications have grown tremendously in recent years. A rise in hospitals' construction activities with the latest equipment magnifies the market's growth. In addition, therapeutic proteins provide high efficiency and quality in biologics manufacture—the increasing familiarity of therapeutic proteins over other drugs fuels the market growth rate.

The research segment will grow with a profitable CAGR growth rate during the forecast period.

Protein Expression Market – By End-User:

  • Biotechnology
  • Pharmaceutics
  • Academia

The biotechnology and pharmaceutical companies hold the largest revenue share in the protein expression market by end-user. In addition, the increasing investments in drug discovery, design, and development contribute to the market demand.

Protein Expression Market – By Region:

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • The Middle East and Africa

Geographically, North America is positioned top in holding a significant market share. The rise in capital income in developed and developing countries is ascribed to bolstering the market's demand. Also, an increased production rate of vaccines and antibodies in pharmaceutical companies will likely outshine the market's demand.

The Asia Pacific is next to North America, holding the largest shares of the market. Increasing acceptance of the latest technological developments and the launch of various products in favor of the end-users are leveraging its growth. Along with this, Changes in the government's schemes and the introduction of reimbursement policies that benefit ordinary people are gearing up the market demand.

Europe is accounted to have the fastest growth rate over recent years and will grow at a constant rate in foreseen years. A growing number of infectious diseases and preferences for new developments in treatment procedures broaden the market demand in this region. Also, the rise in living standards with increased monthly income escalates the market's growth.

Latin America is to have substantial growth opportunities in the coming years. The growing geriatric population and rise in the number of diabetic patients are prompting the market's demand. In addition, the increasing scale of end-users such as dairy, food & beverages, chemical, and pharmaceutical industries across the region are gearing up the market's growth.

The rise in the demand to manufacture quality drugs with fewer or no side effects impacts the market's growth. The Middle East and Africa are anticipated to have a tremendous growth rate in the coming years. Increasing awareness of treatment procedures is propelling the demand of the market. In addition, the emergence of pharmaceuticals and biotechnologies fields in protein expression is leveling up the market's growth.


Major players involved in the global protein expression market are Agilent Technologies, Life Technologies Corporation, Bio-Rad Laboratories, New England BioLabs, Merck Millipore, Takara Bio, Thermo Fisher Scientific, and Promega Corporation.

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What are the key drivers of the protein expression market?

The growing demand for biologics, the growing prevalence of chronic diseases, the increasing investment in research and development, and the need for more efficient and cost-effective protein production methods are majorly driving the growth of the protein expression market.

What are the challenges facing the protein expression market?

The high cost of protein production, the complex regulatory environment, the need for specialized expertise, and the potential for protein misfolding and aggregation are some of the major challenges to the protein expression market.

Who are the key players in the protein expression market?

Thermo Fisher Scientific Inc., Merck KGaA, Agilent Technologies, Inc., Takara Bio Inc., and Qiagen N.V. are some of the notable companies in the protein expression market.

What are some emerging trends in the protein expression market?

Emerging trends in the protein expression market include the use of gene editing technologies to improve protein production, the development of new expression systems, such as cell-free expression systems, and the integration of artificial intelligence and machine learning to optimize protein production.

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