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Global Tangential Flow Filtration Market Size, Share, Trends, COVID-19 Impact & Growth Analysis Report – Segmented By Product, Membrane Material, Technology, Pore size, Application & Region - Industry Forecast (2022 to 2027)

Published: January, 2022
ID: 3328
Pages: 175
Formats: report pdf report excel report power bi report ppt

Tangential Flow Filtration Market Size (2022 to 2027)

The global tangential flow filtration market size was valued at USD 702.46 Million in 2022. It is further estimated to be growing at a CAGR of 12% and worth USD 1237.98 Million by 2027.

Tangential flow filtration, also known as cross-flow filtration, is a useful downstream processing technique used in bio-manufacturing and the upstream cell harvesting process (separation of cells from fermentation broth). The injected solution flows tangentially over the filter's surface, with the pressure difference directing components smaller than the pores through the filter. A wide range of biomolecules, including antibodies, nucleic acids, and recombinant proteins, are separated and purified using tangential flow filtration. This approach has numerous advantages, including the flexibility to be used in various biological domains such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology, as well as its flexibility to a variety of volumes for separation and purification. Tangential flow filtration is used to concentrate and desalt sample solutions ranging from ten milliliters to thousands of liters. It has several benefits, including easy scaling up and scaling down, simple set-up and operation, and time and money savings. It allows researchers to conduct a wide range of biological domains such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology. Approximately 115 vaccine candidates and 155 compounds are currently being developed in the R&D pipeline. 

MARKET DRIVERS:

The increase in the biopharmaceutical sector primarily drives the growth of the global tangential flow filtration market. It includes the benefits of tangential flow filtration over standard flow filtration, the rising usage of single-use technologies, and growing cGMP acceptance. Additionally, the market is likely to grow due to increased investment from pharmaceutical firms, increased acceptance of single-use technologies, and the benefits associated with tangential flow filtering. The other factors driving this market include an increase in biologics manufacturing, investments by large pharmaceutical firms and CMOs in newer facilities to meet expanding biologics demand, and a need for efficient and cost-effective downstream processing technologies in bio-manufacturing.

A wide range of biomolecules, including antibodies, nucleic acids, and recombinant proteins, are separated and purified using tangential flow filtration. This methodology has several advantages, including the capacity to be used in various biological domains such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology, as well as its flexibility to a variety of volumes. Increasing the global usage of single-use TFF systems and the advantages of these completely automated single-use systems are less validation, lower capital costs, and fewer cleaning requirements. Single-pass disposable tangential flow filters might easily fix this problem. As a result, emerging products, such as disposable technologies, have a considerable potential to accelerate the growth of the global tangential flow filtration market throughout the projection period. The current market dynamics have created a demand for innovative manufacturing facility designs that are flexible and productive, allowing for low-cost scale changes in a smaller footprint.

MARKET RESTRAINTS:

The large capital expenditure necessary to build up new manufacturing facilities, on the other hand, is a key factor limiting the growth of the global tangential flow filtration market. Additionally, the availability of rival technologies such as centrifugation, direct flow filtration, and pre-coat filtration is expected to limit the market.

Impact of COVID-19 on the global tangential flow filtration market:

The global pandemic COVID-19 has affected the economy and the different sectors of the market. Pharmaceutical markets have been boosted during the pandemic period. Pharmaceutical and biotech companies, in collaboration with governments throughout the world, are striving to combat the COVID-19 epidemic, from vaccine research to planning for obstacles in the pharmaceutical supply chain. Approximately 115 vaccine candidates and 155 compounds are currently being developed in the R&D pipeline. Furthermore, regularly used medications like Hydroxychloroquine have shown a significant increase in demand for the treatment of COVID-19. Due to the increased demand for these treatments, makers of COVID-19 management medications have a huge potential since many wealthy nations are running out of them. The pharmaceutical and biotechnology industries are predicted to increase significantly due to the demand for COVID-19 vaccines and treatment medications. COVID-19 is predicted to have a substantial influence on the Tangential Flow Filtration Market due to these factors. However, the market is anticipated to witness significant growth during the forecast period.

REPORT COVERAGE:

REPORT METRIC

DETAILS

Market Size Available

2021 to 2027

Base Year

2021

Forecast Period

2022 to 2027

Segments Covered

By Product, Membrane Material, Technology, Pore Size, Application, and Region

Various Analyses Covered

Global, Regional & Country Level Analysis, Segment-Level Analysis, DROC, PESTLE Analysis, Porter’s Five Forces Analysis, Competitive Landscape, Analyst Overview on Investment Opportunities, COVID-19 Impact

Regions Covered

North America, Europe, APAC, Latin America, Middle East & Africa

 

This research report on the global tangential flow filtration market has been segmented and sub-segmented into the following categories and analyzed market size and forecast until 2027.

Tangential Flow Filtration Market - By Product:

  • Single-use Systems
  • Reusable Systems
  • Membrane Filters
  • Filtration Accessories

Based on the product, the membrane filters segment is expected to grow at a higher CAGR during the forecast period due to the benefits over dead-end filters such as high flow rate, less filtration time, high accuracy, membrane fouling, etc. Moreover, the membrane filters are available in various polymers, pore size, and diameters, which have increased the demand dramatically. The membrane filters segment is expected to showcase a CAGR of 7.7% from 2021 to 2026.

Tangential Flow Filtration Market - By Membrane Material:

  • Polyethersulfone
  • Regenerated Cellulose
  • Polyvinylidene fluoride
  • Ceramic

The PES/PS segment is expected to register higher CAGR during the forecast period based on membrane material. The wide range of applications of membrane material is the primary reason for the growth of the segment. Significantly, the hydrophilic feature and the low protein binding properties further fuelling the segment's development.

Tangential Flow Filtration Market - By Technology:

  • Ultrafiltration
  • Microfiltration
  • Reverse Osmosis

Based on the technology, microfiltration is expected to register the highest CAGR during the forecast period. The increasing demand for cell separation in microfiltration is the major reason for the market's growth. Moreover, microfiltration can remove the natural and synthetic organic matter to reduce fouling potential helps the market growth. This technique is also used for removing the biomass from fermentation broths in biotechnology.

Tangential Flow Filtration Market - By Pore Size:

  • Ultrafilters
  • Microfilters
  • Reverse Osmosis Filters

Tangential Flow Filtration Market - By Application:

  • Bioprocessing
  • Product Concentration
  • Purification & Diafiltration
  • Viral Vectors and Vaccine Purification
  • Pharmaceutical Water Production

Based on the application, the viral vectors and the vaccine purification is predicted to grow at an aggressive CAGR during the forecast period. The increase in vaccine safety regulations majorly drives the rapid growth of the segment. Eventually, everything has shifted from old school’s purification methods such as sucrose gradient centrifugation to the most advanced technologies like liquid chromatography and tangential flow filtration, fueling the market growth. Bioprocessing is growing eventually and, the increasing demand for biologics in the pharmaceutical industry is driving factors for the increase in this segment.

Tangential Flow Filtration Market - By Region:

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • The Middle East and Africa

Geographically, the North American market is estimated to account for the largest share in the global tangential flow filtration market during the forecast period. Simultaneously, the Asia Pacific region is expected to witness the fastest growth and overtake North America during the forecast period. The North American market is forecasted to be continuing showing its dominance in the global market throughout the forecast period. Many established biopharmaceutical industries and a massive number of tangential flow filtration markets had boosted the tangential flow filtration market's growth. Moreover, an increase in investments in R&D by pharmaceutical companies fuels the market. The United States is a major contributor to North America's tangential flow filtration market, followed by Canada. The existence of man key players and the country's growing investments are propelling the market's growth. Moreover, pharmaceutical companies mostly use membrane filtration because of its adverse uses, stimulating market growth in the United States and Canada. New inventions are also playing a vital role in the market's growth.

The European tangential flow filtration market is the highest growing CAGR during the forecast period. The United Kingdom is sharing the highest CAGR in Europe. The massive presence of key players is fueling market growth. Moreover, the government policies and the government funding had boosted the market. The investments to launch new products are playing a crucial role in the market's growth. Germany is next to the United Kingdom; rising disposable income in urban areas greatly enhances the demand of the market in this country.

The Asia Pacific tangential flow filtration market is estimated to grow at the highest CAGR during the forecast period. China and India are likely to increase the market because of the enormous population, and the Asia Pacific is the largest growing segment. China is leading the Asia Pacific TFF market with the largest share in the region due to various biological fields like microbiology, biochemistry, molecular biology, immunology, protein chemistry, and biochemistry. Moreover, the research and development of the molecules by the industries are fueling the market. Japan is the second leading country, followed by Australia, India, and South Korea countries throughout the forecast period.

KEY MARKET PARTICIPANTS:

Noteworthy companies operating in the global tangential flow filtration market profiled in the report are GE Healthcare, Merck Millipore, Danaher Corporation, Sartorius Stedim Biotech S.A., and Parker Hannifin Corporation.

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