Vaccine Adjuvant Market

Vaccine Adjuvant Market Size (2023 to 2028)

The size of the global vaccine adjuvant market is forecasted to be worth USD 1187.8 million by 2028 from USD 711.3 million in 2023. The market is estimated to showcase a CAGR of 10.8% during the forecast period.

Vaccine Adjuvant Market Share Insights:

• Based on type, the carbohydrate adjuvants segment held a major market share in 2022.
• Based on the route of administration, the intramuscular segment had the leading market share in 2022.
• Based on the mechanism of action, the immune stimulants segment captured the major share of the market in 2022.
• North America was the largest regional segment worldwide in 2022 and accounted for 36.6% of the global market share.
• The Asia-Pacific region is estimated to grow at a CAGR of 11.73% from 2023 to 2028.

The global vaccine adjuvants market comprises veterinary and human adjuvants, which are used to increase the efficiency of vaccines. In addition, vaccine adjuvants are accredited with assisting in boosting the immune response in the host post-vaccination. Immunologists and infectious disease specialists are in covenant over the advantageous uses of adjuvants in vaccines today. Notably, to decrease the number of doses, surge the probability of a continuous immunological response, and reduce the overall prevalence of the disease. In addition, the immune response to vaccine antigens has been improved with the use of adjuvants for decades. They recover the body's immune reaction and frequently allow fewer deactivated viruses or bacteria to be used in a vaccine. However, the final vaccine product may present more than one adjuvant.

MARKET DRIVERS 

The growing demand for vaccines and the emergence of new diseases propel the vaccine adjuvants market growth.

Across the world, the consumption of vaccines is increasing as it is one of the effective ways to be protected from various diseases. Various governments have been conducting numerous programs to promote vaccination among people, and the awareness levels among people regarding the advantages associated with vaccinations have improved in recent days, which is anticipated to result in the growth of the vaccine adjuvants market. In addition, the growing prevalence of infectious diseases and the introduction of new diseases are promoting the market’s growth rate. For instance, the recent COVID-19 pandemic has increased the demand for vaccines and adjuvants to protect against these diseases.

In addition, the growing incidence of infectious and zoonotic diseases, growing focus on vaccination programs by numerous government bodies, and rising focus on enhanced and long-term immunization besides current and emerging diseases are accelerating the growth rate of the global vaccine adjuvant market. Furthermore, growing R&D expenditure and attainments, associations, and agreements by market participants are other notable factors driving the market's growth. Furthermore, advancements in adjuvant formulations, the growing adoption rate of recombinant subunits, and synthetic vaccines boost the global adjuvant market growth. The growing demand for vaccine adjuvants and untouched market potential in developing countries offer numerous growth possibilities to the adjuvant vaccine manufacturers and key players in the market.

MARKET RESTRAINTS:

However, side effects associated with the adjuvants and high toxicity adjuvants are the primary restraint to the global vaccine adjuvant market. High costs associated with adjuvant-based research and established protection are restraining market growth. The denying effect of adjuvants' toxicity on the vaccine's manufacturing cost and protective profiles inhibits the growing market demand. The adverse effects of adjuvants and high-toxicity adjuvants are factors impeding the vaccine adjuvant market growth during the forecasting timeline. Moreover, insufficient knowledge among people and inadequate healthcare facilities hampers the growing market rate. Low research activities in its development also hinder the market.

Impact of COVID-19 on the global vaccine adjuvant market:

During the pandemic, the lockdown restricted to import and export activities. The COVID-19 pandemic crisis is projected to impact market growth positively, majorly. According to a research article in Nature Reviews Immunology 2020, aluminum-based vaccine adjuvants offer a glide path to influence high levels of neutralizing antibodies identified as a basis of the safety allocated by the COVID-19 vaccines. For instance, in May 2020, GSK considered generating 1 billion doses of its pandemic vaccine adjuvant system in 2021 to develop multiple adjuvanted COVID-19 vaccine candidates. India's government (GOI) has permitted INR 100 crores from PM-CARES funds to establish the COVID-19 vaccine. Presently, nearly 25 vaccine development work is continuous, associated with industry-academia collaboration. Moreover, in April 2020, China announced a surplus funding of USD 30 million to the World Health Organization (WHO) for handling the COVID-19 pandemic. Considering the reduced impact of the COVID-19 pandemic, the global vaccine adjuvant market is anticipated to register a better CAGR during the forecast period.

REPORT COVERAGE:

This market research report on the global vaccine adjuvant market has been segmented based on the type, Route of administration, mechanism of action, and region.

Vaccine Adjuvant Market – By Type:

• Aluminum Salts
• Tensoactive Adjuvants
• Adjuvant Emulsions
• Bacteria Derived Adjuvants
• Liposome Adjuvants
• Carbohydrate Adjuvants

Based on type, the carbohydrate adjuvants segment accounted for a significant market share and is anticipated to grow further during the forecast period.

The aluminum salts segment is estimated to grow at a healthy CAGR during the forecast period due to rising innovation and the introduction of particulate adjuvants. Aluminum salts vaccine has been growing continuously in the market for the last two decades due to the safety of cancer patients. Also, new adjuvants have come up with innovative facilities such as the more muscular battle to disease and having a more shelf life than others due to the easier availability of aluminum salts in nature and the high adoption of particulate vaccines.

Vaccine Adjuvant Market – By Route of administration:

• Oral
• Intradermal
• Subcutaneous
• Intranasal
• Intramuscular

Based on the administration route, the Intramuscular segment dominates the vaccine adjuvants market because this is the fastest and most highly effective Route. On the other hand, the intradermal route segment is likely to contribute a significant market share as it takes more time for absorption and action. 

Vaccine Adjuvant Market – By Mechanism of Action:

• Immune Stimulants
• Carriers
• Vehicle Adjuvants

Based on the mechanism of action, the immune stimulants segment dominates the adjuvant vaccine market owing to the high demand for adjuvants for stimulating antigens to the immune system.

Vaccine Adjuvant Market – By Region:

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East and Africa

Geographically, the North American vaccine adjuvant market led the market in 2021, and the region's domination is likely to continue throughout the forecast period. The rapidly growing geriatric population and rising government funding around R&D of vaccines across North American countries are propelling the adjuvant vaccine market in the North American region. In addition, the growing innovations, increasing product portfolios of key players, and increasing investments to conduct R&D are further favoring the vaccine adjuvant market in the North American region.

The European vaccine adjuvant market had a substantial share of the global market in 201 and is estimated to progress considerably during the forecast period owing to an increase in patients affected by diseases like cancer and other infections. Furthermore, favorable reimbursement policies have been notable factors propelling the regional market growth. In addition, Europe is one of the severely impacted regions by the COVID-19 pandemic, which has further improved the scope of the vaccine adjuvants market in this region.

On the other hand, the Asia Pacific vaccine adjuvant market is anticipated to display a consistent CAGR and is expected to maintain the trend due to the increasing population and diseases like HIV, hepatitis, cancer, influenza, and others. The population in APAC is growing significantly. Countries such as India and China are largely populated countries worldwide. The growing population from the APAC countries is anticipated to demand greater production of vaccines, which is anticipated to have a favorable impact on the regional market growth. The Indian market is expected to grow at a notable CAGR during the forecast period owing to the growing number of awareness campaigns by the Indian government. For instance, the Universal Immunization Program (UIP) is one of the major vaccination programs in India. It provides vaccines for diphtheria, pertussis, tetanus, polio, hepatitis B, measles, mumps, rubella, and Haemophilus influenzae type b (Hib).

The Latin America vaccine adjuvant market is anticipated to showcase a healthy CAGR in the coming years. The growing awareness among the Latin American population regarding the vaccination benefits and increasing incidence of infectious diseases such as influenza and pneumonia propel the regional market growth.

The vaccine adjuvant market in MEA is predicted to occupy a moderate share and grow at a sluggish CAGR during the forecast period.

KEY MARKET PARTICIPANTS:

Some of the promising companies operating in the global vaccine adjuvants market include MPV Technologies (U.S.), Avanti Polar Lipids, Novavax Inc. (U.S.), Brenntag Biosector (Denmark), SEPPIC (France), Agenus, Inc. (U.S.), Invivogen (U.S.), SPI Pharma, Inc. (U.S.), CSL Limited (Australia), and OZ Biosciences (France).

RECENT MARKET DEVELOPMENTS:

• In 2020, The U.S. food and drug administration approved Seqirus for its new product AUNDEZ to treat Influenza prevention. It is the first monovalent vaccine adjuvant to protect against influenza A H5N1 in the pandemic.
• In 2020, GSK announced it would come into the market with innovative doses of vaccine adjuvant to enhance the COVID-19 outbreak. GSK has invested a lot in developing 1 billion doses of adjuvanted vaccine next year.
• In 2018, Croda acquired the Brenntag bio sector to develop an adjuvant vaccine for serving humans and the veterinary market.