Aptamers Market

Global Aptamers Market Size (2023 To 2028)

The global aptamers market size is estimated to grow from USD 282.6 million in 2023 to USD 610.7 million by 2028, progressing at a CAGR of 16.66 % during the forecast period.

Global Aptamers Market Share Insights:

• Based on type, the nucleic acid segment led the market and captured 69.4% of the global market share in 2022.
• North America dominated the market and held 42.6% of the global market share in 2022.
• The European region had a substantial share of the worldwide market in 2022.
• The Asia-Pacific region captured a considerable share of the global market in 2022.

The launch of Macugen, the first aptamer drug and the first diagnostic test for testing mycotoxins in grains, has recognized the potential of aptamers in diagnostics and therapeutics. As a result, the global market for aptamers is expected to grow, backed by technological advancements concerning selection processes and synthesis.

MARKET DRIVERS:

Growing investments in R&D for aptamer development and applications primarily drive market growth. The aptamers market has experienced several investments for R&D by pharmaceutical companies, biotechnology firms, academic institutions and government organizations in recent years and this trend is likely to continue in the coming years. The growing need to explore and harness the unique properties of aptamers for various applications is driving investments for the R&D of aptamers primarily. These investments are majorly used for the development of novel aptamers that can effectively target specific biomarkers associated with diseases such as cancer, cardiovascular disorders, infectious diseases and others.

The growing adoption of technological advancements further boosts the growth rate of the aptamers market. Low cost and high efficacy in binding to large molecules compared to antibodies and the patent expiration of systematic evolution of ligands by exponential enrichment technology (SELEX). The advantages of aptamers such as high specificity, low immunogenicity, and ease of synthesis compared to traditional therapeutics, the growing demand for targeted therapies, rising usage of aptamers in diagnostic assays, biosensors and imaging techniques and rapid shift towards precision medicine fuel the growth rate of the aptamers market.

The growing patient volume suffering from chronic diseases worldwide and increasing support from various governments to conduct R&D around aptamers support the market growth. The growing number of FDA approvals for aptamers, rising awareness among market participants and encouraging pipeline, rapid adoption of aptamers in chemical and food industries and increasing demand among the public due to their benefits, such as their high efficiency and low cost compared to antibodies further drive the global aptamers market growth.

MARKET RESTRAINTS:

Lack of awareness among healthcare professionals, researchers, and end-users about the potential applications and benefits of aptamers is one of the major factors hampering the aptamers market growth. The high costs associated with aptamer development, optimization, and manufacturing, the challenging regulatory landscape for aptamers, the limited availability of commercially viable aptamers and the competition from other established technologies such as antibodies, small molecules, and peptides further impede the aptamers market growth. The stability and manufacturing challenges, limited target diversity, intellectual property concerns, stringent quality control requirements, and ethical and safety considerations are some other significant obstacles to the growth rate of the aptamers market.

Impact of COVID-19 on the global aptamers market:

As COVID-19, which SARS-CoV-2 causes, continues to infect millions of people worldwide, the race to develop new diagnoses, treatments, and preventive measures is more important than ever. As a result, a framework of diagnostics, treatments, and, most critically, vaccinations are being developed to build a complete management regimen. Aptamer, a single-stranded folded RNA or DNA that can bind and detect different nucleic and non-nucleic acid compounds with great affinity and specificity, is one of the new DNA receptors. In recent years, the use of aptamer probes for viral detection has grown. Aptamers, multipotent biological probes, might be great for developing sensitive and specific biosensors. Although just a few types of research have focused on specific coronavirus aptamer types, they may aid in determining the optimal method for obtaining aptamers for this virus. In addition, any viral infection sign, including viral genes, proteins and antibodies, might be detected using aptamers. Aptamers may be beneficial in this pandemic because they may be used to screen for and treat COVID-19, which is particularly beneficial given the limitations of existing techniques due to resource and equipment availability. Considering the factors above, the global aptamers market is expected to showcase healthy growth during the forecast period.

REPORT COVERAGE:

This research report on the global aptamers market has been segmented and sub-segmented based on the type, application, end-user, and region.

Aptamers Market - By Type:

• Peptide Aptamers
• Nucleic Acid Aptamers
  • DNA-Based Aptamers
  • RNA-Based Aptamers
  • XNA-Based Aptamers

Based on type, the nucleic acid segment is anticipated to account for the major share of the global market during the forecast period and witness a promising CAGR. The growing investments from market participants in nucleic acid aptamers to treat various diseases is one of the major factors promoting the segment's growth. The broad target range of nucleic acid aptamers including proteins, small molecules and cells propel the segmental growth. The ease of synthesis and modification, high specificity and affinity for target molecules, the potential for diagnostic and therapeutic applications and the ability to target complex molecular structures further boost the growth rate of the nucleic acid aptamers segment. Under the sub-segments, the DNA-based aptamers sub-segment is anticipated to register dominance during the forecast period, and the growth of the segment is likely to grow at a healthy pace during the forecast period due to increasing research and development initiatives on DNA-based aptamers.

On the other hand, the peptide aptamers segment is estimated to grow at a healthy CAGR during the forecast period owing to the rising usage of peptide aptamers in the diagnostics industry. Versatile binding capabilities of peptide aptamers majorly drive the segmental growth. The ease of chemical synthesis, high stability and resistance to degradation, potential for diverse therapeutic applications and enhanced specificity and affinity for target molecules of peptide aptamers further promote the growth rate of the segment.

Aptamers Market - By Application:

• Therapeutics Development
• Diagnostics
• Research and Development

Based on the application, the diagnostic segment is anticipated to grow rapidly during the forecast period due to a continually increasing population with various diseases leading to a boost in demand for different diagnostic techniques. High sensitivity and specificity of aptamers in detecting disease markers, the potential of aptamers for rapid and accurate detection of biomarkers, a wide range of applications of aptamers in disease diagnosis and monitoring, compatibility of aptamers with various diagnostic platforms and growing demand for point-of-care and molecular diagnostics primarily drive the growth of the diagnostics segment.

On the other hand, the therapeutics development segment is estimated to hold a considerable share of the global market during the forecast period due to factors such as the potential for targeted drug delivery, the ability to inhibit or modulate disease-specific targets and lower risk of off-target effects compared to traditional therapies. The versatility of aptamers in designing aptamers for various diseases and rising interest in personalized medicine approaches further boost the growth rate of the therapeutics development segment.

Aptamers Market - By End User:

• Pharmaceutical Companies
• Bio-Pharmaceutical companies
• Academic and Research Centres

Based on end-user, the academic and research institutes segment held the major share of the global market in 2022 and is likely to grow at a healthy CAGR during the forecast period. The growing demand for aptamers and an increasing number of R&D activities around aptamers from the academic and research centers majorly propel the segmental growth.

Aptamers Market - By Region:

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East and Africa

Regionally, North America dominates the global aptamers market with the highest share, followed by Europe and Asia-Pacific in 2022. The domination of the North American aptamers market is expected to continue growing throughout the forecast period owing to factors such as the growing number of advancements in technology and increasing R&D activities. The strong presence of key market players, the presence of advanced healthcare infrastructure, supportive government initiatives and funding, an increasing number of R&D activities and the rapid adoption of precision medicine approaches further fuel the growth rate of the North American market. The U.S. held the leading share of the North American market in 2022 and is anticipated to grow at a healthy CAGR during the forecast period owing to favorable government initiatives and a rising number of research laboratories.

The aptamers market in the European region was ranked as the second biggest regional market in the global market in 2022 and is projected to grow at a notable CAGR during the forecast period owing to the increasing number of approvals for existing advanced technologies, increasing prevalence of chronic diseases and the rising demand for therapies of aptamers in Europe. The favorable regulatory environment for aptamers in Europe, technological advancements in healthcare, the growing investments in biotechnology and pharmaceutical sectors and the presence of prominent research institutions propel the European aptamers market growth.

APAC is expected to grow at the fastest CAGR among all regions worldwide during the forecast period. The growth of the aptamers market in the Asia-Pacific market is primarily driven by the efforts of the key market players of the developed regions to push into untapped markets. The growing R&D investments in the pharmaceutical and biotechnology industries, increasing patient population base, growing healthcare expenditure, rising emphasis on personalized medicine, growing demand for advanced diagnostic and therapeutic solutions and increasing number of collaborations between international and regional players further promote the growth rate of the APAC market.

The aptamers market in the Latin American region is likely to have a stable CAGR during the forecast period. The growing number of improvements in the healthcare infrastructure across Latin America, increasing awareness about advanced therapies, rising investments in research and development, increasing number of Government initiatives to enhance healthcare access and rising prevalence of chronic diseases drive the growth of the Latin American market.

The aptamers market in the Middle East & Africa region is anticipated to have significant shares due to technological advancements. However, strict regulations for aptamers' usage and ethical issues for aptamers hamper the market growth in this region.

KEY MARKET PLAYERS:

Companies that are playing a leading role in the global aptamers market profiled in the report are AM Biotechnologies, Aptagen, Aptamer Sciences Inc., Aptamer Solutions Ltd, Aptus Biotech S.L, Base Pair Biotechnologies Inc., NeoVentures Biotechnology Inc., SomaLogic Inc., TriLink BioTechnologies Inc., and Vivonics, Inc. The global aptamers market has intense competition with several large-sized, medium-sized, and smaller companies. As a result, the market participants are considering strategies such as R&D investments and product innovations to sustain and improve their market share in the global market.

NOTABLE HAPPENINGS IN THIS MARKET:

• In February 2019, Base Pair Biotechnologies Inc. developed point-of-care tests to diagnose neonatal abstinence syndrome based on aptamer with the SBIR grant's assistance. 
• In January 2019, Aptamer Group announced that the AstraZeneca Company has agreed to collaborate to expand the aptamer technology application potential. With this collaboration, AstraZeneca will adapt to the aptamer group's technology to improve the advanced drug delivery vehicles named after Aptamer Drug Conjugates (ApDCs).