Protein Labelling Market

Global Protein Labeling Market Size

The global protein labeling market was worth USD 2.18 billion in 2024 and is estimated to be worth USD 6.15 billion by 2033 from USD 2.45 billion in 2025, growing at a CAGR of 12.2% during the forecast period. 

Protein labeling detects a labeled protein and its binding partners using the proper molecular labels. Different compounds, including biotin, reporter enzymes, and radioactive isotopes, are tightly bound to the target protein or nucleotide sequence using labeling methods. Proteins are the largest and most important biomolecules in a living organism, as they are essential for survival. Proteins interact with other biomolecules and carry out tasks to keep the cell alive after being produced within a cell. The usage of non-canonical amino acids (ncAAs) followed by conjugation of labeled protein with fluorophores, polymers, affinity reagents, peptides, or nanoparticles has been demonstrated to be successful in proteomics and biotechnology. Protein labeling is becoming increasingly popular. Protein labeling employs a short label to prevent protein folding and function from being disturbed. Immunochemistry, fluorescence in situ hybridization (FISH), cell tracking, receptor tagging, and fluorescence spectroscopy are just a few of the uses for these fluorescent proteins. In addition, biological process monitoring, accurate compound quantification, precise detection of protein changes and isoforms in multiplexed samples, increased detection sensitivity, and simplified detection procedures are some of the most common uses for protein labeling use of IT technology is intended to automate and simplify research and development, as well as increase experimentation and research.

MARKET DRIVERS

Innovation is playing a significant role in the global protein labeling market growth.

Chemically synthesized tags replace reagent and Kit-based protein labeling, probes, and tags through click chemistry and other newer and improved technologies. In addition, synergistic advances in optical physics, probe design, molecular biology, and computational analysis have resulted in the design and development of new protein-labeling technologies that have the potential to propel the future protein labeling market profitably.

In addition, increasing healthcare awareness, rising R&D expenditure, growing technological advancements, innovative products, applications, and services, and the development of proteomics coupled with the development of protein sequencing techniques further accelerate the growth rate of the global protein labeling market. Moreover, computer-controlled fluorescence and laser-confocal microscopy systems are also creating scope for the market.

Furthermore, the growing focus of governments on improving the healthcare infrastructure, increasing proteomics research, and increasing research and development spending for research activities is expected to provide a favorable environment for the global protein labeling market to explore further. Adopting modern molecular biology and bioengineering tools to intensify functional mechanism knowledge on a subcellular scale under both pathologic and psychological conditions leads to drug development, diagnosis, and therapy applications. With the bioengineering tools, the usage label in the detection & purification of proteins and diagnostic tests based on detecting a particular protein has grown significantly.  The market represents several new product launches, and the rising adoption of bioengineering technologies is expected to accelerate the market growth.

MARKET RESTRAINTS

However, a lack of skilled professionals and awareness and high product costs hinder the growth of the global protein labeling market.

REPORT COVERAGE

SEGMENTAL ANALYSIS

By Product Insights

The reagents segment had the highest share of the global protein labeling market in 2024. However, in-vitro labeling accounted for a larger revenue share due to ongoing clinical investigation studies concerning the proteomic analysis of genetic data. As a result, an increase in the number of labeling agents and genetically engineered labels is discovered, expected to calculate the percentage of the reagents segment. As a result, the protein segment held a significant share of protein labeling in terms of revenue share in the reagent segment. 

By Labelling Insights

The in vitro labeling segment is estimated to account for most market share during the forecast period based on the labeling. Reagents, instruments, and systems are intended for use in the diagnosis of diseases and other conditions. The in vitro labeling procedure takes approximately 25 minutes and doesn’t require centrifugation to separate from bound 99mTc.

By Application Insights

The Immunological techniques segment represents the largest segment with a higher market share based on the application. Flow cytometry, immunoassays, western blotting, and immunofluorescence are immunological techniques that involve in use of labels. These techniques are primarily used in cancer research, autoimmune disease research, and therapeutic development.

REGIONAL ANALYSIS

North America occupied the largest share of the global market in 2023 and is anticipated to continue showing domination in the global market during the forecast period owing to the increasing adoption of technological advancements, demand for protein labeling products, and rise in R&D investments. In addition, the growing number of companies offering protein labeling services and increasing R&D activities from academic and research institutions across North American countries are anticipated to propel regional market growth.

Europe accounted for a substantial share of the global market in 2023 and is expected to register a healthy CAGR during the forecast period. Factors include well-established healthcare infrastructure for R&D activities, rising demand for protein-based drugs, and growing need for protein analysis in applications such as drug discovery and disease diagnosis.

Asia-Pacific is the fastest-growing region in the worldwide market due to the increased demand of emerging economies such as Japan, India, and China, rising investment in genomic and proteomic research, and healthcare expenditure. In addition, the growing adoption of protein labeling techniques and increasing efforts from market participants are expected to fuel the market’s growth rate.

Latin America and MEA are estimated to hold a moderate global market share in the coming years.

KEY MARKET PLAYERS

Some of the notable companies dominating the global protein labeling market profiled in this report are Thermo Fisher Scientific, Inc., General Electric Company, Merck KGaA, Eurogentec S.A., PerkinElmer, Inc., F. Hoffmann-La Roche AG, New England Biolabs, Kaneka Corporation, Kirkegaard & Perry Laboratories, Promega Corporation, LI-COR, Inc. and SeraCare Life Sciences, Inc.

RECENT MARKET HAPPENINGS

• Abcam, a UK-based developer and distributor of protein research tools, said in January 2020 that it had agreed to buy Expedeon's Proteomics and Immunology division, which comprises Innova and TGR Biosciences.
• Researchers from the National Institutes of Health (US) demonstrated the application of a bi-arsenical dye system that allows the fluorescence detection of proteins in various cellular locations in August 2019 by researchers from the National Institutes of Health (US).

MARKET SEGMENTATION

This research report on the global protein labeling market has been segmented and sub-segmented based on the product, labeling, application, and region.

By Product

• Reagents 
  • Enzymes
  • Monoclonal Antibodies
  • Proteins
  • Probes/Tags
  • Other Reagents
• Kits
• Services

By Labeling

• In vitro Labeling
  • Enzymatic Labeling
  • Dye-Based Labeling
  • Cotranslational Labeling
  • Site-Specific Labeling
  • Nanoparticle Labeling
• In vivo Labeling
  • Photoreactive Labeling
  • Radioactive Labeling

By Application

• Cell-Based Assay
• Mass Spectroscopy
• Fluorescence Microscopy
• immunological Technique
• Protein Microarray

By Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa