As per our report, the global intravenous ibuprofen market size was worth USD 9.8 billion in 2023. This figure is estimated to grow at a CAGR of 20.0% and reach USD 24.57 billion by 2028.
Some of the key findings of the report:
Based on the age group, the pediatrics segment is estimated to lead the intravenous ibuprofen market during the forecast period.
Based on the indication, Pain/inflammatory management will dominate the segment during the forecast period.
Geographically, North America and Europe accounted for most of the market share in 2022 and forecasted that North America would continue as the leading region throughout the forecast period.
Intravenous ibuprofen is a type of parenteral dosage form containing anti-inflammatory action that can protect from infective agents. It is a non-steroid anti-inflammatory agent that inhibits cyclooxygenase COX-1 and COX-2 enzymes that control the synthesis of prostaglandins. Ibuprofen injection is also used to reduce pain in the menstrual cycle. The Food and Drug Administration has approved color ibuprofen for pediatric and adult patients.
Treatment of acute and postoperative pain and fever with nonsteroidal anti-inflammatory agents (NSAIDs) using the first intravenous ibuprofen product approved in the United States used alone or with other medications like opioid painkillers to relieve patients. A type of IV ibuprofen, Toradol, also called ketorolac, is a pain reliever that decreases prostaglandins.
The major factors driving the growth of the intravenous ibuprofen market are high bioavailability with rapid action and increasing diseases like CVS, osteoarthritis, rheumatoid arthritis, cancer, and headache.
The easy availability of ibuprofen over the counter across the world is enhancing market growth. In addition, increasing awareness about rapid pain relief injections and pharmaceutical industries focusing on developing innovative drugs is accelerating the market demand. Also, the rise in disposable income in urban areas is increasing the market's growth rate. Furthermore, due to the implementation and advancement in technology and investment in R&D, it will foresee the growth of the ibuprofen injection market. In addition, the increase in the prevalence of arthritis, increasing incidence of bone and muscle disorders, increase in the prevalence of musculoskeletal diseases, increasing cardiovascular diseases and cancer, and high development of intravenous ibuprofen formulations in the global market of intravenous (IV) ibuprofen is driving the growth market.
IV Ibuprofen provides several benefits. Due to the direct analgesic and anti-inflammatory effects, combined with reduced opioid requirements, help patients recover faster and reduce opioid-related side effects when surgical patients are treated with intravenous ibuprofen. When used in conjunction with central and peripheral nerves, IV ibuprofen may even show additional synergistic multimodal analgesic effects, like the hospital floor for general pain management, the emergency department for musculoskeletal injuries, and ambulatory surgery centers to expedite discharge and limit the use of narcotics.
Additionally, increased investment in research and development activities and technological advancements would further drive the market's growth. Shortened ibuprofen IV infusion shows robust Cmax to potentiate the analgesic effect. During the postoperative period, acute pain is a significant problem for hospitalized patients, resulting in trauma or acute illness due to surgical procedures, which is experienced by 80% of people. The sympathetic nervous system is activated by pain, increasing blood pressure, and respiratory rate, which is often not well treated by hospitals and long-term care facilities, but IV ibuprofen solves that problem.
Additionally, the increasing number of product approvals and government regulations for NSAIDs provide lucrative opportunities for the market. NSAIDs inhibit the production of the enzymes COX-1 and COX-2 to further prevent sensitization of pain receptors at the site of injury; when used with Oral ibuprofen, it provides additional properties of anti-inflammatory, antipyretic and analgesic, acting as a mainstay in the treatment of acute pain and fever. Furthermore, due to improved government regulations, previously faced limitation of lack of a commercially available parenteral formulation has been solved through its lipophilic properties to produce it in an intravenous formulation, which works mechanically, both centrally and peripherally, to reduce pain and fever. These factors further help in driving the market growth.
Prostaglandins and COX enzymes vasodilating properties help maintain renal blood flow and glomerular filtration, and suppressing their production lowers perfusion and reduces renal function. However, side effects such as respiratory depression, drowsiness, allergic responses, and gastrointestinal issues frequently restrict their use. Some common side effects of ibuprofen injection may include vomiting, headache, dizziness, or nausea. However, the side effects of intravenous ibuprofen injection in the market and it taking a long time to introduce new products are some factors hampering the Intravenous ibuprofen global market.
Impact of COVID-19 on the global intravenous ibuprofen market:
The coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses, is rapidly spreading worldwide. Fever, dry cough, tiredness, sore throat, diarrhea, and other clinical symptoms are typical in people infected with SARS-CoV-2. Intravenous (IV) ibuprofen is a nonsteroidal anti-inflammatory medication (NSAID) used to relieve or treat pain, fever, and inflammation caused by a disease, surgical procedures, trauma, or acute illness. For the treatment of postoperative and acute pain, IV ibuprofen is preferred. In addition, the side effects of opioid analgesics, such as respiratory depression, allergic reactions, sedation, and gastrointestinal events, have increased the demand for ibuprofen. However, several factors, such as the lengthy approval process and the restricted geographic approvals, will likely hinder the market growth. In the United States, intravenous (IV) ibuprofen is the first, and only NSAID approved for pain and fever control in adults. According to multicenter research, IV ibuprofen is safe and efficient in postoperative pain relief for abdominal hysterectomy and orthopedic procedures. On the other hand, World Health Organization (WHO)does not advise against using ibuprofen based on current research. This decreased the shares of the market.
Market Size Available
2022 to 2028
2023 to 2028
By Age Group, Indication, and Region
Various Analyses Covered
Global, Regional & Country Level Analysis, Segment-Level Analysis, Drivers, Restraints, Opportunities, Challenges; PESTLE Analysis; Porter's Five Forces Analysis, Competitive Landscape, Analyst Overview of Investment Opportunities
North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa
This research report on the global intravenous ibuprofen market has been segmented based on age group, indication, and region.
Intravenous Ibuprofen Market – By Age Group:
Based on the age group, Adults are the significant consumer base for intravenous ibuprofen. The adult medication is injected into a vein for 30 minutes every 6 hours to reduce pain. To reduce fever, medication is given every 4 to 6 hours, which works by lowering body temperature and blocking certain substances that cause inflammation or fever. The maximum effect is reached within 5-10 minutes, lasting 2-4 hours. It might also be life-threatening if more than 400 mg/kg of ibuprofen is ingested.
The pediatric segment is expected to grow at a substantial rate. The Pediatrics segment is estimated to be the quickest-growing segment during the forecast period. Increasing awareness about Intravenous ibuprofen and increasing funds from government organizations escalate market growth. IV ibuprofen used for 10 minutes in children is an analgesic option for perioperative, intraoperative, and postoperative pain, which is even more safe and more effective for short-term use. A single oral dose is bioequivalent to a single IV of the same volume.
Intravenous Ibuprofen Market - By Indication:
Based on the Indication, the fever segment is projected to grow at the most significant share from 2023 to 2028. Rising incidences of chronic diseases are propelling the demand of the market. Ibuprofen 400 mg IV and acetaminophen 1000 mg IV are used to reduce fever in a short period of 30 min. Acetaminophen injection is injected into a vein over 15 minutes, relieving fever for the next 4 to 6 hours.
Pain/inflammatory management is also foreseen to dominate in this segment. IV ibuprofen is a crucial addition to perioperative pain management in any surgical setting by reducing the narcotic analgesic requirements with an excellent safety profile.
Intravenous Ibuprofen Market - By Region:
Middle East and Africa
In 2019, the North American intravenous ibuprofen market was the most dominant and significant global intravenous ibuprofen market share. The U.S. and Canada are estimated to remain the highest income-producing region in this region. This market's growth is credited to the extensive use of intravenous ibuprofen for treating pain and fever.
The European intravenous ibuprofen market is estimated to grow at a CAGR value of 19.23% during the forecast period and has occupied the second-largest market share. Increasing awareness among people, particularly in adults, and Soaring occurrences of heart-related disorders and cancer significantly drive the market.
The Asia-pacific intravenous ibuprofen market is expected to grow with the highest CAGR value during the period. Rising awareness of nonsteroidal anti-inflammatory drugs and transferring tendency associated with intravenous drug delivery are fuelling the market's growth rate.
The Latin American intravenous ibuprofen market is evaluated to grow prominently during the period. Furthermore, increasing occurrences of cardiovascular diseases and growing support from the government are escalating the intravenous ibuprofen market growth.
The Middle East & Africa intravenous ibuprofen market is expected to reach USD 1.55 billion by 2024. This region is attributed to pain, fever, headache, toothache, back pain, and trauma.
KEY MARKET PARTICIPANTS:
Some of the major companies dominating the Global Intravenous Ibuprofen Market profiled in the report are Cumberland Pharmaceuticals Inc., Alveda Pharmaceuticals, Inc., CSL Limited, Sandor Medicaids Pvt Ltd., Germin MED, Grifols S.A., Harbin Gloria Pharmaceuticals Co., Ltd., Al Nabeel International Ltd., PT. Soho Industri Pharmasi and Laboratorios Valmorca, C.A.
RECENT MARKET DEVELOPMENTS:
In July 2022, a comprehensive response letter was received by Hyloris Pharmaceuticals from the United States Food and Drug Administration for clarification of Maxigesic IV, a combination of 1000 mg of acetaminophen and 300 mg of ibuprofen, to treat fever and postoperative pain.
In November 2021, a specialty pharmaceutical company, Cumberland Pharmaceuticals Inc., announced the approval of Caldolor by the U.S. Food and Drug Administration, a formulation of ibuprofen administered intravenously, given just before surgery, and administered every six hours afterward.
In November 2021, a combination of acetaminophen 1000 mg and ibuprofen 300 mg for intravenous (IV) infusion, Maxigesic, was accepted as a New Drug Application by Food and Drug Administration to be used for the treatment of postoperative pain.
In January 2020, Cumberland, a pharmaceutical company, announced a new product, caldolor, to treat acute care. The latest version of caldolor is taken directly without dilution for pain relief. In addition, Caldolor is an anti-inflammatory agent that helps to reduce mild-moderate pain.
In 2020, Cumberland Pharmaceuticals began expanding its caldolor business worldwide to treat coronavirus infections. In addition, the company provides support through caldolor access to hospitals and clinics in various countries.
In 2020, Nashville pharmaceutical company might reduce opioid use by launching a new product, ibuprofen, in an IV bag. This IV bag helps to decrease the need for opioid analgesic drugs post-surgery.
North America is dominate the intravenous ibuprofen market during the forecast period.
The intravenous ibuprofen market is expected to grow at a CAGR of 20.0% during the forecast period 2023-2028.
As per our research report, the global intravenous ibuprofen market size is estimated to grow to USD 24.57 billion by 2028.
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