Protein Sequencing Market

Global Protein Sequencing Market Size

The global protein sequencing market was valued at USD 1,145 million in 2024. The global market is anticipated to grow at a CAGR of 5.77% from 2025 to 2033 and be worth USD 1,897 million by 2033 from USD 1,211 million in 2025.

Protein sequencing is a sequencing technology that uses the mass spectrum to determine and analyze the amino acid sequence. Researchers can use this method to learn more about protein structure. Protein sequencing has become a popular high-throughput proteomic technology with various applications, and protein sequencing is done using various computational and experimental methods, including Edman degradation and mass spectrometry. Several biotechnology and pharmaceutical businesses are investing heavily in protein sequencing as a tool for medication development. Furthermore, advances in high-throughput technology have enabled rapid and parallel protein sequencing. Even modest amounts of protein can be sequenced at high resolution to aid in the characterization of gene products and subcellular structures.

MARKET DRIVERS

The increased focus of biotechnology and pharmaceutical companies on target-based medication development operations in various developing and developed areas is one of the factors propelling the global protein sequencing market growth.

Technological developments in mass spectrometers are a good example. Individual peptide residues may now be detected due to improvements in nanopore sensors and single-molecule fluorescent devices. In addition, the market is being supported by increased funding for proteomics research in several emerging and developed countries. An increase in demand for protein biomarkers in the drug development process is one of the significant factors accelerating the market’s growth rate.

Protein sequencing is gathering steam as a tool for detecting new peptides in human antibodies, and antigens are becoming more widely used. Nonetheless, technological developments in identifying isobaric residues in protein sequences are projected to open up a large number of new opportunities in the global protein sequencing market. Furthermore, developments in clinical mass spectrometry and analytical methodologies are expected to drive the protein sequencing market growth over the forecast period. In addition, new business opportunities have arisen due to recent advancements in de novo peptide sequencing and analytical technologies and the usage of neural networks.

MARKET RESTRAINTS

High infrastructure costs would constrain the market's expansion during the forecast period. In addition, over the forecast period, factors such as the preparation of pure protein samples and the requirement for qualified researchers and laboratory personnel will challenge the global protein sequencing market's expansion.

REPORT COVERAGE

SEGMENTAL ANALYSIS

By Product & Service Insights

The launch of technologically advanced instruments, software, and services for protein sequencing, the high cost of sequencing infrastructure, the complexities associated with protein sequencing procedures, and the availability of advanced sequencing infrastructure among service providers are all factors driving growth in the protein sequencing services segment.

By Application Insights

Protein Engineering Studies is predicted to be the fastest-growing segment in terms of application. Protein engineering is manipulating protein structures to achieve desired qualities or the creation of proteins with specific architectures. Bioformulations such as antibodies, nucleic acid products, and vaccines make up the bulk of therapeutic medications on the market today. The incorporation of unnatural amino acids is a field in protein engineering that firms concentrate on for site-specific conjugation of functional moieties to biopharmaceuticals.

By End-User Insights

Based on the end-user, the academic institutes & research centers segment led the global protein sequencing market in 2021 due to governmental and private institutes' increased funding for proteome research. Protein sequencing is used in proteomic research at academic institutes and research centers. However, these institutes rely on protein sequencing suppliers to conduct proteomic research due to a lack of infrastructure, a limited number of samples, and budget limits to buy protein sequencing consumables. Protein sequencing services, such as mass spectrometry and Edman degradation, are also available through numerous academic institutes and research organizations.

REGIONAL ANALYSIS

Because of increased technological advancements and a more robust healthcare infrastructure, North America is likely to be the most significant protein sequencing market. The pharmaceutical sector in the United States is one of the most research-intensive industries. And the pharmaceutical business is heavily committed to implementing advanced solutions to improve pipeline development and patient care. Furthermore, there is a growing emphasis on target-based medication development, with protein sequencing studies assisting in creating target-based drugs. Additionally, both government and non-government entities are funding research in proteomics.

Europe has the world's second-largest market share. The expansion of the protein sequencing market in Europe is likely to be fueled by an increase in demand for protein sequencing and increased awareness.

During the forecast period, the protein sequencing market in the Asia Pacific is expected to account for a large share of the protein sequencing market in terms of value. During the projection period, China is expected to have the quickest growth rate. In addition, increasing government initiatives and investments in life science research and development in countries like Japan and India will likely boost the growth of the protein sequencing market over the forecast period.

KEY MARKET PARTICIPANTS

Companies playing a vital role in the global protein sequencing market profiled in this report are Thermo Fisher Scientific, Inc., Shimadzu Corporation, Agilent Technologies, SGS S.A., Rapid Novor, Charles River Laboratories, Bioinformatics Solutions, Proteome Factory, Selvita, and Waters Corporation.

RECENT HAPPENINGS IN THIS MARKET

• Shimadzu expanded its mass spectrometry platform in 2018 by introducing a new Q-TOF instrument.
• NIST introduced TMAP in 2019 to allow NIST scientists and engineers to bring their lab-created ideas to market quickly. TMAP (Technology Maturation Accelerator Program) is a platform that aims to help numerous technologies get over the "valley of death" that occurs between the prototype and implementation stages.

MARKET SEGMENTATION

This research report on the global protein sequencing market has been segmented and sub-segmented into the following categories.

By Product & Service

• Sample Preparation Products & Services
• Protein Sequencing Products
• Reagents & Consumables
• Instruments
• Analysis Products/Software
• Protein Sequencing Services

By Application

• Biomarker Discovery
• Protein Engineering Studies
• Biotherapeutics

By End-User

• Academic Institutes & Research Centers
• Pharmaceutical & Biotechnology Companies

By Region

• North America
• Europe
• Asia Pacific
• Latin America
• The Middle East and Africa